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1.
Dr. Thomas Le Bihan Dr. Cathryn H. S. Driver Dr. Thomas Ebenhan Dr. Nathalie Le Bris Dr. Jan Rijn Zeevaart Prof. Dr. Raphaël Tripier 《ChemMedChem》2021,16(5):809-821
An improved glucose-chelator-albumin bioconjugate (GluCAB) derivative, GluCAB-2Mal, has been synthesized and studied for in vivo 64Cu-PET/CT imaging in breast cancer mice models together with its first-generation analogue GluCAB-1Mal. The radioligand works on the principle of tumor targeting through the enhanced permeability and retention (EPR) effect with a supportive role played by glucose metabolism. [64Cu]Cu-GluCAB-2Mal (99 % RCP) exhibited high serum stability with immediate binding to serum proteins. In vivo experiments for comparison between tumor targeting of [64Cu]Cu-GluCAB-2Mal and previous-generation [64Cu]Cu-GluCAB-1Mal encompassed microPET/CT imaging and biodistribution analysis in an allograft E0771 breast cancer mouse model. Tumor uptake of [64Cu]Cu-GluCAB-2Mal was clearly evident with twice as much accumulation as compared to its predecessor and a tumor/muscle ratio of up to 5 after 24 h. Further comparison indicated a decrease in liver accumulation for [64Cu]Cu-Glu-CAB-2Mal. 相似文献
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Under the circumstance of perceptual consumption, it is still challenging to grasp consumer's emotions and demands due to the large search space, diversified preferences, and easy fatigue of consumers. To reduce user fatigue and enlarge search space, a novel method was presented to design and optimize the pattern of yarn-dyed plaid fabric using the isolation niche genetic algorithm and rough set theory. Each pattern was encoded as a chromosome based on the real number code. The population was initialized and evolved using INGA to maintain the diversity. The rough set theory was adopted as the fitness function of isolation niche genetic algorithm to extract the consumer's demands. After multiple evolutions, a large set of practical patterns of the yarn-dyed plaid fabric are obtained. Experiments were carried out by 24 testers of different ages and genders. The results prove that the proposed method based on the isolation niche genetic algorithm and rough set theory is feasible and effective, supplying references to the designer. 相似文献
3.
Yarn-dyed fabric is often woven from warp and weft yarns in the same color depth to ensure a uniform color appearance. The difference in color depth between warp and weft tends to result in the uneven color of the yarn-dyed fabric. This article aims to establish a color tolerance for yarn-dyed fabric that can be woven with a qualified color appearance but from the warp and weft yarns in different color depths. A total of 27 yarn-dyed fabric samples in three color series (red, yellow, and blue) were evaluated by using the yarn-dyed fabric from warp and weft yarns in the same color depth of 2% (on weight of fabric, owf) as the standard. Visual assessment and instrumental measurement of color were carried out to establish the color tolerance ellipse that was defined as CMC (Color Measurement Committee) color differences (2:1) of no more than 1.00. It was found that the color strengths (K/S) and color differences (ΔECMC(2:1)) of these fabric samples for each color series had linear relationships with the color depths of warp and weft yarns. The color tolerance ellipses indicated that, even though the warp and weft yarns had an apparent color difference, they could be woven in fabrics with relatively uniform color appearance and meet the requirements for yarn-dyed fabric. This work provided valuable insight into the production of qualified yarn-dyed fabrics from unqualified dyed yarns. 相似文献
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由外伤或肿瘤骨转移造成的隐匿性骨折和愈合情况的准确诊断对制定合适的治疗方案具有非常重要的意义。为考查18F-NaF PET显像用于骨折诊断的诊断效能,本研究制备了18F-NaF注射液,并对其进行了质量控制和稳定性研究,然后建立新西兰兔骨折动物模型,模型建立约2周后进行了18F-NaF PET显像和99Tcm-亚甲基二磷酸盐(99Tcm-MDP)SPECT显像的自身对照实验,并对显像效果进行了比较。结果表明:18F-NaF的产量大于37 GBq,各项检验结果均符合质控要求,40 ℃下放置8 h和30 ℃下放置10 h所有检验结果均无明显变化;18F-NaF PET和99Tcm-MDP SPECT两种显像方式均可见全身骨骼,骨折部位呈明显放射性浓聚,但18F-NaF给药后30 min即可进行PET显像,骨折部位显示更为清晰,骨折部位与对侧正常骨骼的放射性摄取比(T/NT)明显高于99Tcm-MDP,而99Tcm-MDP需在给药后2 h才能进行SPECT显像。本研究表明18F-NaF PET对骨折的显像性能优于99Tcm-MDP,可明显提高检查流通量和诊断效能。 相似文献
7.
为给纺织行业在纺织品贸易和质量控制等方面优选色差公式提供参考,研究了3个重要的和1个最新色差公式的色差均匀性,借助国际上色样多、视觉等距性好的汉风色典,利用X-Rite测色仪测试近2万个色样的色度参数,然后分别从向度、彩度、浓度3个方向选取3万多对相邻色样,采用MatLab编程计算4种色差并统计分析其均值、不匀率和性能因子。结果表明:不同方向不同评价指标所得结果不尽相同;在色差均匀性方面,CAM16-UCS最好,CIEDE2000(2∶1∶1)略优于CMC(2∶1),且二者明显优于CIELAB;在色差大小方面由小到大依次为CIEDE2000(2∶1∶1)、CMC(2∶1)、CAM16-UCS、CIELAB。 相似文献
8.
Mohamed Janshir Bin Gulam Mohamed Hafiz Abdul Mannan Rizwan Nasir Dzeti Farhah Mohshim Hilmi Mukhtar Aymn Abdulrahman Anas Ahmed 《应用聚合物科学杂志》2020,137(12):48476
Membrane technology has been considered a key factor for sustainable growth in high-efficiency gas separation. Current mixed matrix membranes (MMMs) technology is rising, but these membranes in the dense structure are having difficulties in operating at high pressures and scale up for commercialization. The purpose of this research is to synthesize composite MMMs (CMMMs) consisting of polyethersulfone (PES), carbon molecular sieve (CMS 1–5 wt %), and Novatex 2471 nonwoven fabric (support layer). The membranes' physical, chemical, and thermal properties were evaluated by different analytical equipment. The morphology of both PES and PES-CMS composite membranes had a porous and asymmetric structure, in which CMS was uniformly distributed in the polymer matrix. The thermal properties showed that the membranes were stable up to 350 °C with a single glass transition temperature. The functional groups in the membrane were confirmed by spectral analysis. The gas performance results showed that carbon dioxide permeance increased with increased CMS concentration and methane permeance decreased due to the hindering effect of CMS under similar operating conditions. The highest selectivity achieved was 12.774 using CMMM of 5 wt % of CMS at 10 bar, which on average was 137.80%, improved selectivity compared to pure PES membrane. The support layer was able to withstand high operating pressures and showed the ability to scale up. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020 , 137, 48476. 相似文献
9.
In this research, the three‐dimensional structural and colorimetric modeling of three‐dimensional woven fabrics was conducted for accurate color predictions. One‐hundred forty single‐ and double‐layered woven samples in a wide range of colors were produced. With the consideration of their three‐dimensional structural parameters, three‐dimensional color prediction models, K/S‐, R‐, and L*a*b*‐based models, were developed through the optimization of previous two‐dimensional models which have been reported to be the three most accurate models for single‐layered woven structures. The accuracy of the new three‐dimensional models was evaluated by calculating the color differences ΔL*, ΔC*, Δh°, and ΔECMC(2:1) between the measured and the predicted colors of the samples, and then the error values were compared to those of the two‐dimensional models. As a result, there has been an overall improvement in color predictions of all models with a decrease in ΔECMC(2:1) from 10.30 to 5.25 units on average after the three‐dimensional modeling. 相似文献
10.
采用普通涤纶、含1%云母颗粒的涤纶(1%云母/涤纶)以及含5%云母颗粒的涤纶(5%云母/涤纶)三种材质,上机纬密采用200根/10 cm、300根/10 cm、400根/10 cm,组织采用平纹、斜纹、缎纹试织试样。通过Hot Disk热常数分析仪,采用正交试验及极差、方差分析,研究了纤维材质、上机纬密、组织对凉感纤维织物导热系数的影响。结果表明:在试验设置变量范围内,纤维材质对导热系数的影响显著,上机纬密、组织对导热系数的影响高度显著,影响因素从大到小顺序为上机纬密>组织>纤维材质。 相似文献